Design of liquid-liquid chromatographic processes: from molecule to process
The overall objective of this project is to establish a general approach (rules) for the development of liquid-liquid chromatographic separation processes on a technical scale; for both batch and continuous separations and a wide range of specific bioproduct separation as well as purification problems. The method should guide the user in the selection of mobile and stationary phases (both liquids in liquid-liquid chromatography), operating mode and operating conditions toward accomplishment of pre-set separation requirements. The input information of the considered approach is: molecular structure of the target component and adjacent impurities, separation purpose (mixture fractionation, target component capturing or polishing) and required separation performances (purity, yield, productivity). All parameters affecting the separation efficiency (thermodynamics, hydrodynamics and mass transfer) as well as the possible operating modes are taken into consideration. The aim is to develop a model-based separation process design procedure and to minimize the experimental effort for the determination of the parameters governing the process.
References
- J. Völkl, W. Arlt, M. Minceva “Theoretical study of sequential centrifugal partition chromatography” AIChE J., 59, 241–249, 2013.
- E. Hopmann, J. Goll, M. Minceva, “Sequential centrifugal partition chromatography: a new continuous chromatographic technology” Chem. Eng. Technol. 35, 72-82, 2012.
- E. Hopmann, M. Minceva “Separation of a binary mixture by sequential centrifugal partition chromatography” J. Chromatogr. A, 1229, 140–147, 2012.
- J. Goll, A. Frey, M. Minceva, “Study of the separation limits of continuous solid support free liquid-liquid chromatography: Separation of capsaicin and dihydrocapsaicin by centrifugal partition chromatography” J. Chromatogr. A, 1284, 59-68, 2013.
Research funded by:
“True Moving Bed Centrifugal Partition Chromatography Unit” - DFG Großgeräte-Projekt